It revolves around the lives to three sisters, Prue, Piper and Phoebe who discover they are witches and come form a line of very powerful good witches. Prue, the eldest, discovers she has the ability to move objects with her mind (telekinesis). She often uses this ability when angry. Piper, the middle child, discovers she has teh power to freeze time and unintentionally freezes objects and people when she's frightened. Phoebe, the youngest, discover's she can see the future via premonitions that occur when touching objects that relate to that event. Not only are the sisters witches, but they're the most powerful witches of all time known as The Charmed Ones. Later in the third season, Prue dies by being killed by a demon. Rose McGowan took over Shannen Doherty's spot as Paige, the long lost fourth sister who was adopted after birth.
- Shannen Doherty as Prue Halliwell (seasons 1-3)
- Holly Marie Combs as Piper Halliwell
- Alyssa Milano as Phoebe Halliwell
- Rose McGowan as Paige Matthews (seasons 4-8)
- Brian Krause as Leo Wyatt
- Kaley Cuoco as Billy Jenkins (season 8)